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dc.contributor.authorFogg, Carole
dc.contributor.authorBajunirwe, Francis
dc.contributor.authorPiola, Patrice
dc.contributor.authorBiraro, Samuel
dc.contributor.authorChecchi, Francesco
dc.contributor.authorKiguli, James
dc.contributor.authorNamiiro, Proscovia
dc.contributor.authorMusabe, Joy
dc.contributor.authorKyomugisha, Agnes
dc.contributor.authorGuthmann, Jean-Paul
dc.date.accessioned2021-11-23T10:04:20Z
dc.date.available2021-11-23T10:04:20Z
dc.date.issued2004
dc.identifier.citationFogg, C., Bajunirwe, F., Piola, P., Biraro, S., Checchi, F., Kiguli, J., ... & Guthmann, J. P. (2004). Adherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Uganda. The American journal of tropical medicine and hygiene, 71(5), 525-530.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/981
dc.descriptionADHERENCE TO A SIX-DOSE REGIMEN OF ARTEMETHER-LUMEFANTRINE .en_US
dc.description.abstractMeasuring baseline levels of adherence and identifying risk factors for non-adherence are important steps beforetheintroductionofnewantimalarials.InMbararainsouthwesternUganda,weassessedadherencetoartemetherlumefantrine (Coartem ) in its latest World Health Organization blister formulation. Patients with uncomplicated Plasmodium falciparum malaria were prescribed artemether-lumefantrine and received an explanation of how to take the following five doses at home. A tablet count was made and a questionnaire was completed during a home visit. Among 210 analyzable patients, 21 (10.0%) were definitely or probably non-adherent, whereas 189 (90.0%) were probably adherent. Age group was not associated with adherence. Lack of formal education was the only factor associated with non-adherence after controlling for confounders (odds ratio 3.1, 95% confidence interval [CI] 1.1−9.7). Mean lumefantrine blood levels were lower among non-adherent (n 16) (2.76 g/mL, 95% CI 1.06−4.45) than among adherent (n 171) (3.19 g/mL, 95% CI 2.84−3.54) patients, but this difference was not statistically significant. The high adherence to artemether-lumefantrine found in our study suggest that this drug is likely to be very effective in Mbarara provided that patients receive clear dosage explanations.en_US
dc.language.isoenen_US
dc.publisherThe American Society of Tropical Medicine and Hygiene.en_US
dc.subjectADHERENCE,SIX-DOSE REGIMEN,ARTEMETHER-LUMEFANTRINE ,PLASMODIUM FALCIPARUM .en_US
dc.titleAdherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated plasmodium falciparum malaria in Ugandaen_US
dc.typeArticleen_US


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