Department of Pharmacy: Recent submissions
Now showing items 121-140 of 188
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Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats
(BMC complementary medicine and therapies, 2022)Background: Several local communities in Central, Western, Eastern, and Northern regions of Uganda have been using the whole leaf extracts of Aloe vera (L.) Burm. f. (Asphodelaceae) in the treatment of various ailments. ... -
Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study
(Evidence-Based Complementary and Alternative Medicine, 2022)Introduction: Uganda National Drug Authority requires phytochemical screening, freedom from microbial contamination, and evidence of safety and efficacy of the constituent plants to register herbal products. Since Uganda ... -
Potential drug-drug interactions on in-patient medication prescriptions at Mbarara Regional Referral Hospital (MRRH) in western Uganda: prevalence, clinical importance and associated factors
(African Health Sciences, 2011)Background: Drug-drug interactions (DDIs) are an important cause of adverse drug reactions. The pharmacoepidemiology of such interactions in hospitals in Uganda is not known. Objectives: To determine the prevalence, ... -
Inappropriate usage of selected antimicrobials: Comparative residue proportions in rural and urban beef in Uganda
(PloS one, 2019)Introduction In most developing countries like Uganda, antimicrobials including β-lactams and tetracyclines are used indiscriminately in livestock. When livestock get sick and treatment is necessary, some producers and ... -
Prevalence and risk factors of nephrotoxicity among adult cancer patients at Mbarara regional referral hospital
(Dove Medical Press Limited., 2021-10-17)Background: Nephrotoxicity is common among cancer patients, yet some anti-cancer drugs, for example, platinum derivatives, are nephrotoxic and have narrow therapeutic indices. If nephrotoxicity is not managed, it can ... -
Artemisia annua L.- Vernonia amygdalina Del: A Potential Herbal Artemisinin Combination Treatment against Malaria
(British Journal of Pharmaceutical Research, 2016-01)Aim of Study: The aim of the study was to determine the potential of Vernonia amygdalina - Artemisia annual combination as a possible herbal artemisinin combination treatment of malaria. Place and Duration of Study: Study ... -
Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial
(Malaria journal, 2012-05)Background: Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, randomized controlled trial in Mbarara, Uganda ... -
Potential benefits of antiviral African medicinal plants in the management of Viral infections
(Frontiers in Pharmacology, 2021-12-24)Background: Viruses cause various human diseases, some of which become pandemic outbreaks. This study synthesized evidence on antiviral medicinal plants in Africa which could potentially be further studied for viral ... -
Antifungal activity of Cleome gynandra L. aerial parts for topical treatment of Tinea capitis: an in vitro evaluation
(Complementary and Alternative Medicine, 2016-07)Background: Cleome gynandra L. (Capparaceae) is an edible weed used in Uganda topically for its presumed antifungal activity against Tinea capitis. The goal of this study was to determine if this plant possesses antifungal ... -
Poor Glycemic Control and the Contributing Factors Among Type 2 Diabetes Mellitus Patients Attending Outpatient Diabetes Clinic at Mbarara Regional Referral Hospital, Uganda
(2021)Background: Glycemic control is associated with long-term complications in type 2 diabetes management. However, updated reports on glycemic control that are crucial to reducing diabetes mellitus complications remain ... -
Phytochemical and Antidiabetic Evaluation of the Methanolic Stem Bark Extract of Spathodea campanulata (P. Beauv.) Bignoniaceae
(Pharmacognosy Journal, 2016-05)Background: Spathodea campanulata (P. Beauv.) Bignoniaceae extract (SCE) is one of many herbal medicines used widely in Ugandan traditional medicine for various ailments. Generally most of these herbal medicines are yet ... -
Infections
(African Health Sciences, 2011-09)Background: Medicinal plants in Uganda and other developing countries have been scientifically demonstrated to have medicinal benefits but few or none have been translated to products for clinical use. Most herbal products ... -
Antisickling effect of crude flavonoids in the methanolic leaf extract of Persea americana Mill
(Revista Cubana de Plantas Medicinales, 2019-06)Introduction: Sickle-cell anemia, a difficult-to-treat genetic disease, causes synthesis of abnormal hemoglobin in which erythrocytes assume a sickle shape and become susceptible to hemolysis. Research about Persea americana ... -
Anticonvulsant and anxiolytic activity of the leaf aqueous and ethanolic extracts of Melanthera scandens in a rat model
(HHS Public Access, 2016)Modern drug therapy of epilepsy is complicated by the inability of drugs to control seizures in some patients and side effects that range in severity from minimal impairment of the central nervous system to death from ... -
Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
(Pharmacology & Pharmacy, 2018)Oral lesions, diarrhoea, Pneumocystis carinii pneumonia, tuberculosis and urinary tract infections are some of the opportunistic infections (OIs) which arise when the CD4 cells of the HIV/AIDS patient fall below 200 ... -
Aflatoxins metabolism, effects on epigenetic mechanisms and their role in carcinogenesis
(SciRes, 2013)Chronic consumption of aflatoxin-contaminated foods is a global problem in both developing and developed countries especially where there is poor regulation of their levels in foods. In the body, aflatoxins (AFBs) mainly ... -
An investigation into the number and nature of the urgent care consultations managed and referred by community pharmacists in South-East England
(Primary Health Care Research & Development, 2020)Background: Community pharmacies are recognised as an under-utilised, accessible resource that could support the urgent care agenda. This study aimed to provide a snapshot of the number and nature of urgent care requests ... -
Adverse drug reaction reporting among health care workers at Mulago National Referral and Teaching hospital in Uganda
(African Health Sciences, 2015)Background: Adverse Drug Reactions (ADRs) are an important contributor to patient morbidity and hospitalisation in Uganda. Under-reporting of ADRs may increase medicine-induced morbidity and mortality among patients. This ... -
Poor glycemic control and the contributing factors among type 2 diabetes mellitus patients attending outpatient diabetes clinic at Mbarara regional referral hospital, Uganda
(Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2021)Background: Glycemic control is associated with long-term complications in type 2 diabetes management. However, updated reports on glycemic control that are crucial to reducing diabetes mellitus complications remain scarce. ... -
Physical properties and compactability of various blends of fully gelatinised and pregelatinised maize starch
(Pharmaceutical and Biosciences Journal, 2020)The use of pregelatinised maize starch in direct compression as a sole binder produces tablets with relatively low tensile strength. Fully gelatinised maize starch possesses better binding properties but its use is limited ...