Pharyngeal carriage of Neisseria meningitidis in 2—19-year-old individuals in Uganda
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Date
2006Author
Cauganta, Dominique A.
Foggd, Carole
Bajunirwe, Francis
Piola, Patrice
Twesigye, Rogers
Mutebi, Fred
Frøholma, L. Oddvar
Rosenqvist, Einar
Batwala, Vincent
Aaberge, Ingeborg S.
Rottingen, John-Arne
Guerin, Philippe J.
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In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2—19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.
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