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dc.contributor.authorFeinstein, Matthew J.
dc.contributor.authorKim, June-Ho
dc.contributor.authorBibangambah, Prossy
dc.contributor.authorSentongo, Ruth
dc.contributor.authorMartin, Jeffrey N.
dc.contributor.authorC., Alexander
dc.contributor.authorTsai, Alexander C.
dc.contributor.authorBangsberg, David R.
dc.contributor.authorHemphill, Linda
dc.contributor.authorTriant, Virginia A.
dc.contributor.authorBoum, Yap
dc.contributor.authorHunt, Peter W.
dc.contributor.authorOkello, Samson
dc.contributor.authorSiedner, Mark J.
dc.date.accessioned2022-01-24T13:35:22Z
dc.date.available2022-01-24T13:35:22Z
dc.date.issued2017
dc.identifier.citationSentongo, M. D., David, R., Bangsberg, M. D., Hemphill, L., Hunt, P. W., & Okello, S. Ideal Cardiovascular Health and Carotid Atherosclerosis in a Mixed Cohort of HIV-Infected and Uninfected Ugandans Running Title: HIV and Ideal Cardiovascular Health in Uganda Matthew J. Feinstein MD, June-Ho Kim MD 2, Prossy Bibangambah MD 3, Ruth.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/1278
dc.description.abstractPreventable cardiovascular disease (CVD) risk factors are responsible for the majority of CVD-related deaths, and are increasingly recognized as a cause of morbidity and mortality for HIV-infected persons taking antiretroviral therapy (ART). Simplified tools such as the American Heart Association’s ideal cardiovascular health (iCVH) construct may identify and prognosticate CVD risk in resource-limited settings. No studies have evaluated iCVH metrics in sub-Saharan Africa or among HIV-infected adults. Thus, the central aim of this study was to compare levels of iCVH metrics and their correlations with carotid atherosclerosis for HIV infected adults versus uninfected controls in a well-phenotyped Ugandan cohort. We analyzed the prevalence of iCVH metrics in a mixed cohort of HIV-infected persons on stable ART and uninfected, population-based comparators in Mbarara, Uganda. We also assessed the validity of iCVH by correlating iCVH values with common carotid intima media thickness (CCIMT). HIV-infected persons had a mean of 4.9 (SD 1.1) iCVH metrics at ideal levels versus 4.3 (SD 1.2) for uninfected controls ( p = .002). This difference was largely driven by differences in blood pressure, blood glucose, and diet. In multivariable-adjusted linear regression models, each additional iCVH metric at an ideal level was associated with a significant 0.024mm decrease in CCIMT ( p < .001).HIV-infected persons on ART in rural Uganda had more iCVH metrics at ideal levels than uninfected persons. The difference appeared driven by factors that are putatively influenced by access to routine medical care. Composite scores of iCVH metrics were associated with subclinical atherosclerosis and more predictive of atherosclerosis for uninfected personsen_US
dc.description.sponsorshipNational Institutes of Health (P30 AI027763 and R01 MH054907, and R21 HL 124712).en_US
dc.language.isoen_USen_US
dc.subjectCardiovascularen_US
dc.subjectCarotid Atherosclerosisen_US
dc.subjectMixed Cohorten_US
dc.subjectHIV-Infecteden_US
dc.subjectUninfected Ugandansen_US
dc.titleIdeal Cardiovascular Health and Carotid Atherosclerosis in a Mixed Cohort of HIV-Infected and Uninfected Ugandansen_US
dc.typeArticleen_US


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