Browsing Research Articles by Issue Date
Now showing items 1-20 of 54
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The Analgesic and Antiplasmodial Activities and Toxicology of Vernonia amygdalina
(Journal of medicinal food, 2008)Vernonia amygdalina possesses several bioactive compounds and is used in traditional medicines of southwestern Uganda, along with other regions. Its analgesic potential has not been investigated thus far. The present study ... -
Plants used to treat malaria in Nyakayojo sub-county, western Uganda
(Journal of Ethnopharmacology, 2011)Aim of study: We performed an ethnobotanical study of plants used to treat malaria in Nyakayojo subcounty in south western Uganda because malaria in this region, and in Uganda at large, is still the single most important ... -
Khat (Catha edulis) and ethanol co-dependence modulate seizure expression in a pentylenetetrazol seizure model
(Journal of Ethnopharmacology, 2011)Ethnopharmacological relevance: Khat is a plant with psychostimulant properties whose parts, mainly leaves and twigs, are chewed for its euphoriant effects. Khat use and ethanol abuse are increasingly becoming global health ... -
Expression of cFos and brain‑derived neurotrophic factor in cortex and hippocampus of ethanol‑withdrawn male and female rats
(Journal of Pharmacology and Pharmacotherapeutics, 2013)Objective: To map areas of brain activation (cFos) alongside changes in levels of brain-derived neurotrophic factor (BDNF) to provide insights into neuronal mechanisms contributing to previously observed sex differences ... -
Registration, procurement, distribution, and use of misoprostol in Uganda: an interview-based observational study
(The Lancet, 2013)Background: Poor access to essential medicines remains a barrier to improvement of health in low-income countries. The maternal mortality rate from post-partum haemorrhage (PPH) in Uganda is one of the highest in the world. ... -
Chronic khat (Catha edulis) and alcohol marginally alter complete blood counts, clinical chemistry, and testosterone in male rats
(Journal of Experimental Pharmacology, 2013)Introduction: Khat (Catha edulis) is a recreational psychoactive drug with psychostimulant properties. While the use of this drug is widespread in eastern Africa, including the Horn of Africa, surveys and anecdotal data ... -
Prevalence and factors associated with use of herbal medicine among women attending an infertility clinic in Uganda
(BMC Complementary and Alternative Medicine, 2014)Background: Infertility is a public health problem associated with devastating psychosocial consequences. In countries where infertility care is difficult to access, women turn to herbal medicines to achieve parenthood. ... -
Association of testosterone levels with socio-demographic characteristics in a sample of Ugandan men
(African Health Sciences, 2014)Background: Testosterone, a male reproductive hormone, affects several physiological processes, such as sperm production, energy, strength, sexual behavior, sleep and the general wellbeing of men. Normal levels of testosterone ... -
Safety and antidiarrheal activity of Priva adhaerens aqueous leaf extract in a murine model
(Journal of Ethnopharmacology, 2014)Ethnopharmacological relevance: Priva adhaerens (Forssk.) Chiov., a wildly growing plant, is reported in central Uganda to be. An effective traditional remedy for diarrhea. The objective of this study was to provide a ... -
The availability of six tracer medicines in private medicine outlets in Uganda
(Journal of Pharmaceutical Policy and Practice, 2014)Objectives: Many low income countries struggle to provide safe and effective medicines due to poor public health care infrastructure, budgetary constraints, and lack of human resource capacity. Private sector pharmacies ... -
Evaluation of the Acute and Sub chronic Toxicities of the Methanolic Stem Bark Extract of Spathodea campanulata (P. Beauv.) Bignoniaceae
(British Journal of Pharmacology and Toxicology, 2015)Spathodea campanulata (P. Beauv.) Bignoniacea is widely used in Ugandan traditional medicine without having much knowledge on any toxicity data. This study carried out the toxicity profile of its methanolic stem bark extract ... -
Tackling sexually transmitted infection burden in Ugandan communities living in the United Kingdom: a qualitative analysis of the socio-cultural interpretation of disease and condom use
(African Health Sciences, 2015-09)Background: Despite being in a different country and social environment, Ugandans living in the UK still reportedly have the lowest rates of condom usage and one of the highest incidences of STIs in UK. In Uganda, STIs and ... -
An Evaluation of Factors Affecting Drug Quality: Evidence from the Antimalarial Market in Uganda
(University of Massachusetts Boston, 2015-10-28)The quality of healthcare, and specifically medicines, is reportedly low in developing countries. We purchase and test 879 antimalarial drugs from 459 outlets in 44 randomly selected parishes (131 villages) in Uganda to ... -
Projection neurons in the cortex and hippocampus: differential effects of chronic khat and ethanol exposure in adult male rats
(Journal of Experimental Pharmacology, 2016)Background: Recent evidence suggests that many individuals who chew khat recreationally also drink ethanol to offset the stimulating effect of khat. The objective of this study was to describe the separate and interactive ... -
Potential Cost-Effectiveness of Prenatal Distribution of Misoprostol for Prevention of Postpartum Hemorrhage in Uganda
(PLoS ONE, 2016-11-11)Background: In settings where home birth rates are high, prenatal distribution of misoprostol has been advocated as a strategy to increase access to uterotonics during the third stage of labor to prevent postpartum hemorrhage ... -
Acute and Sub-Acute Toxicity Study of Ethanolic Crude Extract of Mitracarpus hirtus Plant on Wistar Rats
(International Journal of Science and Healthcare Research, 2017)Background: Plants are still considered among the important source of bioactive compound, especially in traditional medicine that has been used for centuries. Ethno botanical survey showed that Mitracarpus hirtus is used ... -
Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model
(Journal of Basic and Clinical Physiology and Pharmacology, 2018)Background: Caffeine antagonizes the intoxicating effects of alcohol. Consequently, there has been a dramatic global increase in the consumption of caffeinated drinks together with alcohol, especially among young adults. ... -
Frogs and Lizards as Potential Drug Sources- a Mini Review
(Current Trends in Complementary and Alternative Medicine, 2018)Today, the world is heavily weighed down by emerging health complications which are exacerbated by the emergency of Multi Drug Resistant (MDR) microorganisms. This is happening despite the search for new and better drugs ... -
African Progress in Drug Development Chemistry; a 100 Years Update
(2018)Africa is currently very active in the search for drugs particularly with focus on the preclinical phases of drug discovery. This work aimed at determining the extent to which Africa has gone with research and studies in ... -
Factors associated with delayed onset of active labor following administration of vaginal Misoprostol among women at Mbarara Regional referral hospital, Uganda: A prospective cohort study
(Research square, 2019)Background: Vaginal misoprostol has been recommended by the World Health Organization as one of the effective methods for induction of labor. Globally 9.6% of all deliveries follow induction of labor. Although the goal of ...
