dc.contributor.author | Magodoro, Itai M. | |
dc.contributor.author | Okello, Samson | |
dc.contributor.author | Dungeni, Mongiwethu | |
dc.contributor.author | Castle, Alison C. | |
dc.contributor.author | Mureyani, Shakespeare | |
dc.contributor.author | Danaei, Goodarz | |
dc.date.accessioned | 2023-09-19T10:07:47Z | |
dc.date.available | 2023-09-19T10:07:47Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Magodoro, I. M., Okello, S., Dungeni, M., Castle, A. C., Mureyani, S., & Danaei, G. (2022). Association between HIV and Prevalent Hypertension and Diabetes Mellitus in South Africa: Analysis of a Nationally Representative Cross-Sectional Survey. International Journal of Infectious Diseases, 121, 217-225. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/3112 | |
dc.description.abstract | Objectives: Cardiovascular diseases (CVD) burden is rising among persons living with HIV (PLWH) in sub-Saharan Africa. It is unclear whether this reflects absolute increase in HIV-related CVD risk or unmasking by improved survival. We, therefore, examined whether HIV is associated with adverse cardiometabolic profiles among South African adults.
Methods: We analyzed a nationally-representative dataset (n=6,420), estimating weighted prevalence of hypertension, diabetes, and 10-year predicted risk of incident fatal/non-fatal CVD (if ≥40 years old). Associations between HIV and cardiometabolic indices were assessed using log-binomial regression models adjusted for sociodemographic factors.
Results: HIV population prevalence was 18.9% with median age of 36.0 years. Hypertension (44.2 vs. 45.4%), diabetes (18.6 vs. 20.4%) and overweight/obesity (BMI ≥25 kg/m2: 54.9 vs. 52.0%) prevalence did not substantially differ by HIV status, although PLWH had lower 10-year predicted CVD risk (median: 5.1 vs. 13.5%). In adjusted models, HIV- females had a 5 mmHg higher median systolic blood pressure (128 vs. 123 mmHg) than female PLWH.
Conclusions: PLWH in South Africa have better cardiometabolic disease profiles than the general population, and social determinants, rather than HIV, may have a greater influence on cardiometabolic risk. Designating PLWH a CVD high-risk group in South Africa is likely unwarranted. | en_US |
dc.description.sponsorship | The Fogarty International Center and National Institute of Mental Health of the National Institutes of Health (D43 TW010543), career development grant from the Fogarty International Institute of the National Institutes of Health (K43TW010715).,career development grants from the Fogarty International Center (D43 TW010543) and the National Institute of Allergy and Infectious Diseases (T32 AI007433) of the National Institutes of Health. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | International Journal of Infectious Diseases | en_US |
dc.subject | HIV | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Diabetes | en_US |
dc.subject | Obesity | en_US |
dc.subject | Cardiometabolic disease | en_US |
dc.subject | South Africa | en_US |
dc.title | Association between HIV and Prevalent Hypertension and Diabetes Mellitus in South Africa: analysis of a nationally representative cross-sectional survey | en_US |
dc.type | Article | en_US |