dc.contributor.author | Hale, Gila | |
dc.contributor.author | Adzemovic, Tessa | |
dc.contributor.author | Hullsiek, Kathy Huppler | |
dc.contributor.author | Mulwana, Suzan | |
dc.contributor.author | Ndyetukira, Jane Francis | |
dc.contributor.author | Sadiq, Alisat | |
dc.contributor.author | Kabahubya, Mable | |
dc.contributor.author | Ayebare, Peruth | |
dc.contributor.author | Nankungu, Lydia | |
dc.contributor.author | Namudde, Alice | |
dc.contributor.author | Namanda, Sylvia | |
dc.contributor.author | Menya, Grace | |
dc.contributor.author | Nakitto, Grace | |
dc.contributor.author | Muzoora, Conrad | |
dc.contributor.author | Nuwagira, Edwin | |
dc.contributor.author | Rhein, Joshua | |
dc.contributor.author | Meya, David B. | |
dc.contributor.author | Boulware, David R. | |
dc.contributor.author | Ellis, Jayne | |
dc.contributor.author | Abassi, Mahsa | |
dc.date.accessioned | 2024-08-20T10:09:51Z | |
dc.date.available | 2024-08-20T10:09:51Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Hale, G., Adzemovic, T., Huppler Hullsiek, K., Mulwana, S., Ndyetukira, J. F., Sadiq, A., ... & Abassi, M. (2024). Mid–Upper Arm Circumference Is a Strong Predictor of Mortality Among Ugandan Adults With HIV-Associated Cryptococcal Meningitis: A Prospective Cohort Study. In Open Forum Infectious Diseases (Vol. 11, No. 7, p. ofae354). US: Oxford University Press. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/3746 | |
dc.description.abstract | Background: Mortality among adults diagnosed with HIV-associated cryptococcal meningitis remains high (24%–40%). We hypothesized that nutritional state, as measured by mid–upper arm circumference (MUAC), is a potentially modifiable risk factor for mortality.
Methods: Ugandan adults hospitalized with HIV-associated cryptococcal meningitis had MUAC measurements performed at baseline. We compared MUAC measurements with baseline clinical and demographic variables and investigated associations with survival using Cox regression.
Results: Of 433 participants enrolled, 41% were female, the median CD4 T-cell count (interquartile range [IQR]) was 15 (6–41) cells/μL, and 37% were antiretroviral therapy naïve. The median MUAC (IQR) was 24 (22–26) cm, the median weight (IQR) was 53 (50–60) kg, and MUAC correlated with weight (Pearson r = 0.6; P < .001). Overall, 46% (200/433) died during the 18-week follow- up. Participants in the lowest MUAC quartile (≤22 cm) had the highest mortality: 39% (46/118) at 2 weeks and 62% (73/118) at 18 weeks. A baseline MUAC ≤22 cm was associated with an 82% increased risk of 18-week mortality as compared with participants with an MUAC >22 cm (unadjusted hazard ratio, 1.82; 95% CI, 1.36–2.42; P < .001). Following adjustment for antiretroviral therapy status, CD4 count, hemoglobin, amphotericin dose, and tuberculosis status, the adjusted hazard ratio was 1.84 (95% CI, 1.27–2.65; P < .001). As a continuous variable, 18-week mortality was reduced by 10% for every 1-cm increase in MUAC. CSF Th17 immune responses were positively associated with MUAC quartile. Conclusions: MUAC measurement is a simple bedside tool that can identify adults with HIV-associated cryptococcal meningitis at high risk for mortality for whom an enhanced bundle of care, including nutritional supplementation, should be further investigated. | en_US |
dc.description.sponsorship | United Kingdom Medical Research Council (MR/M007413/1) | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Open Forum Infectious Diseases | en_US |
dc.subject | Cryptococcal meningitis | en_US |
dc.subject | HIV | en_US |
dc.subject | Malnutrition | en_US |
dc.subject | Mid–upper arm circumference | en_US |
dc.subject | Mortality | en_US |
dc.title | Mid–Upper Arm Circumference Is a Strong Predictor of Mortality Among Ugandan Adults With HIV-Associated Cryptococcal Meningitis: A Prospective Cohort Study | en_US |
dc.type | Article | en_US |