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dc.contributor.authorAppeadu-Mensah, William
dc.contributor.authorMdoka, Cecilia
dc.contributor.authorAlemu, Seifu
dc.contributor.authorYifieyeh, Abiboye
dc.contributor.authorKaplamula, Tiya
dc.contributor.authorOyania, Felix
dc.contributor.authorChagaluka, George
dc.contributor.authorAbera Mulugeta, Gersam
dc.contributor.authorKudowa, Evaristar
dc.contributor.authorYimer, Mulugeta
dc.contributor.authorRenner, Lorna Awo
dc.contributor.authorPaintsil, Vivian
dc.contributor.authorChitsike, Inam
dc.contributor.authorMolyneux, Elizabeth
dc.contributor.authorAtwiine, Barnabas
dc.contributor.authorKouya, Francine
dc.contributor.authorPritchard-Jones, Kathy
dc.contributor.authorAbdelhafeez, Hafeez
dc.contributor.authorDessalegne, Andient
dc.contributor.authorMbuwayesango, Bothwell
dc.contributor.authorGeorges, Ngock
dc.contributor.authorIsraels, Trijn
dc.contributor.authorBorgstein, Eric
dc.date.accessioned2024-11-26T07:15:21Z
dc.date.available2024-11-26T07:15:21Z
dc.date.issued2024
dc.identifier.citationAppeadu‐Mensah, W., Mdoka, C., Alemu, S., Yifieyeh, A., Kaplamula, T., Oyania, F., ... & Borgstein, E. (2024), Surgical aspects and outcomes after nephrectomy for Wilms tumour in sub‐Saharan Africa: A report from Wilms Africa Phase II—CANCaRe Africa. Pediatric Blood & Cancer, e31134.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/3949
dc.description.abstractBackground: Wilms tumour (WT) is one of the common and curable cancer types targeted bytheGlobalInitiativeforChildhoodCancer.Tumourexcisionisessentialfor cure. This analysis focuses on surgical outcomes of patients with WT in sub-Saharan Africa. Methods: We implemented a risk-stratified WT treatment guideline as a multicentre, prospective study across eight hospitals and six countries. Eligibility criteria were age 6 monthsto16 years, unilateral WT, surgery performed after preoperative chemotherapy and diagnosed between 1 January 2021 and 31 December 2022. Data collection included a specific surgical case report form(CRF). Results: The study registered 230 patients, among whom 164 (71.3%) had a nephrectomy. Ninety-eight percent of patients had a completed surgical CRF. Out 164 patients, 50 (30.5%) had distant metastases. Median tumour diameter at surgery was 11.0 cm. Lymphnode sampling was done in 122(74.3%) patients,34(20.7%) had intraoperative tumour rupture, and for 18 (10.9%), tumour resection involved en bloc resection of another organ. Tumour size at surgery was significantly correlated with tumour rupture (p<.01). With a median follow-up of 17 months (range:2–33),23(14.0%) patients have relapsed. Twenty-two (13.4%) patients abandoned treatment post nephrectomy. Two-year event-free survival was 60.4% ± 4.7% with treatment abandonment as an event. Conclusion: Survival post nephrectomy is challenged by treatment abandonment, treatment-related mortality and relapse. Large tumours after preoperative chemotherapy were associated with a higher risk of tumour rupture. Earlier diagnosis and access to radiotherapy are expected to improve survival.en_US
dc.description.sponsorshipInternational Society of Paediatric Oncology (SIOPPARC) Program to Advance Research Capacity in LMICs and Foundation S—My Child Mattersen_US
dc.language.isoen_USen_US
dc.publisherPediatric Blood & Canceren_US
dc.subjectAfricaen_US
dc.subjectNephrectomyen_US
dc.subjectNephroblastomaen_US
dc.subjectResource-limited settingsen_US
dc.subjectSurgeryen_US
dc.subjectSurvivalen_US
dc.subjectWilmsen_US
dc.titleSurgical aspects and outcomes after nephrectomy for Wilms tumour in sub-Saharan Africa: A report from Wilms Africa Phase II—CANCaRe Africaen_US
dc.typeArticleen_US


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