Research Article: Recent submissions
Now showing items 81-100 of 141
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Hypoglycemic, Antihyperglycemic, and Toxic Effects of Physalis peruviana L. Aqueous and Methanolic Leaf Extracts in Wistar Rats
(Journal of Experimental Pharmacology, 2022)Background: Physalis peruviana L. (Solanaceae) is a plant widely used in traditional medicine systems to manage various diseases, including diabetes mellitus, which remains a global health problem in developing and developed ... -
Registration, procurement, distribution, and use of misoprostol in Uganda: an interview-based observational study
(The Lancet, 2013-10-20)Background: Poor access to essential medicines remains a barrier to improvement of health in low-income countries. The maternal mortality rate from post-partum haemorrhage (PPH) in Uganda is one of the highest in the world. ... -
Prevalence of Medication Errors and the Associated Factors: A Prospective Observational Study Among Cancer Patients at Mbarara Regional Referral Hospital
(Cancer Management and Research, 2021)Background: Medication error is one of the most common medical errors in the practice of modern medicine. Among cancer patients receiving chemotherapy, medication errors can be potentially harmful given the narrow therapeutic ... -
Correction: Potential Cost-Effectiveness of Prenatal Distribution of Misoprostol for Prevention of Postpartum Hemorrhage in Uganda
(PLOS ONE, 2016-03-21)The correct sentences are “In the base-case analysis, misoprostol distribution lowered the expected incidence of PPH by 1.2% (95% credibility interval (CrI): 0.55%, 1.95%), mortality by 0.08% (95% CrI: 0.04%, 0.13%) and ... -
Civil Society Organizations and medicines policy change: A case study of registration, procurement, distribution and use of misoprostol in Uganda
(Social Science & Medicine, 2015-02-18)Misoprostol use for postpartum haemorrhage (PPH) has been promoted by Civil Society Organizations (CSOs) since the early 2000s. Yet, CSOs' role in improving access to misoprostol and shaping health policy at global and ... -
Factors Associated With Non-Adherence To Antidiabetic Medication Among Patients at Mbarara Regional Referral Hospital, Mbarara, Uganda
(Research square, 2021)Background: Non–adherence is a major concern in treatment of diabetes mellitus and undermines the goals of treatment. The objective of this study was to determine the magnitude of non-adherence and its contributing factors ... -
Prevalence and factors associated with adverse drug events among patients on dolutegravir‑based regimen at the Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: a mixed design study
(AIDS Research and Therapy, 2022)Background: In low income countries such as Uganda progress has been made towards achieving the United Nations AIDS programme 95-95-95 target however efforts are still impeded by pretreatment drug resistance and adverse ... -
Antipyretic and Antinociceptive Properties of the Aqueous Extract and Saponin from an Edible Vegetable- Vernonia Amygdalina Leaf
(African Journal of food, agriculture, nutrition and development, 2013)Vernonia amygdalina is commonly used for food and health purposes. The processing of the leaf for food is usually aimed at removing bitter tasting principles like saponins. This study was designed to determine the antipyretic ... -
Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?
(World journal of pharmacology,, 2014)Artemisinin from the plant Artemisia annua (A. annua) L., and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in ... -
Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats
(BMC complementary medicine and therapies, 2022)Background: Several local communities in Central, Western, Eastern, and Northern regions of Uganda have been using the whole leaf extracts of Aloe vera (L.) Burm. f. (Asphodelaceae) in the treatment of various ailments. ... -
Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study
(Evidence-Based Complementary and Alternative Medicine, 2022)Introduction: Uganda National Drug Authority requires phytochemical screening, freedom from microbial contamination, and evidence of safety and efficacy of the constituent plants to register herbal products. Since Uganda ... -
Inappropriate usage of selected antimicrobials: Comparative residue proportions in rural and urban beef in Uganda
(PloS one, 2019)Introduction In most developing countries like Uganda, antimicrobials including β-lactams and tetracyclines are used indiscriminately in livestock. When livestock get sick and treatment is necessary, some producers and ... -
Prevalence and risk factors of nephrotoxicity among adult cancer patients at Mbarara regional referral hospital
(Dove Medical Press Limited., 2021-10-17)Background: Nephrotoxicity is common among cancer patients, yet some anti-cancer drugs, for example, platinum derivatives, are nephrotoxic and have narrow therapeutic indices. If nephrotoxicity is not managed, it can ... -
Artemisia annua L.- Vernonia amygdalina Del: A Potential Herbal Artemisinin Combination Treatment against Malaria
(British Journal of Pharmaceutical Research, 2016-01)Aim of Study: The aim of the study was to determine the potential of Vernonia amygdalina - Artemisia annual combination as a possible herbal artemisinin combination treatment of malaria. Place and Duration of Study: Study ... -
Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial
(Malaria journal, 2012-05)Background: Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, randomized controlled trial in Mbarara, Uganda ... -
Potential benefits of antiviral African medicinal plants in the management of Viral infections
(Frontiers in Pharmacology, 2021-12-24)Background: Viruses cause various human diseases, some of which become pandemic outbreaks. This study synthesized evidence on antiviral medicinal plants in Africa which could potentially be further studied for viral ... -
Antifungal activity of Cleome gynandra L. aerial parts for topical treatment of Tinea capitis: an in vitro evaluation
(Complementary and Alternative Medicine, 2016-07)Background: Cleome gynandra L. (Capparaceae) is an edible weed used in Uganda topically for its presumed antifungal activity against Tinea capitis. The goal of this study was to determine if this plant possesses antifungal ... -
Phytochemical and Antidiabetic Evaluation of the Methanolic Stem Bark Extract of Spathodea campanulata (P. Beauv.) Bignoniaceae
(Pharmacognosy Journal, 2016-05)Background: Spathodea campanulata (P. Beauv.) Bignoniaceae extract (SCE) is one of many herbal medicines used widely in Ugandan traditional medicine for various ailments. Generally most of these herbal medicines are yet ... -
Infections
(African Health Sciences, 2011-09)Background: Medicinal plants in Uganda and other developing countries have been scientifically demonstrated to have medicinal benefits but few or none have been translated to products for clinical use. Most herbal products ...