Research Article: Recent submissions
Now showing items 61-80 of 141
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Traditional Approaches and Medicinal Plants in Treatment of Epilepsy in West and East Africa
(NeuroPharmac Journal, 2020)Background: Epilepsy has affected over sixty million people around the globe. Traditionally, communities have opted for complementary and alternative medicines (CAM) to help in the treatment of epilepsy which has worked ... -
Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda
(TMR Integrative Medicine, 2023)Different parts of Artemisia vulgaris L. (A. vulgaris) are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever, ulcers, and cancer. However, anecdotal evidence shows that the ... -
Retrospective in silico mutation profiling of SARS-CoV-2 structural proteins circulating in Uganda by July 2021: Towards refinement of COVID-19 disease vaccines, diagnostics, and therapeutics
(Plos one, 2022)The SARS-CoV-2 virus, the agent of COVID-19, caused unprecedented loss of lives and economic decline worldwide. Although the introduction of public health measures, vaccines, diagnostics, and therapeutics disrupted the ... -
Association between Pre-Hospital Antibiotic Exposure and Level of Bacterial Resistance (PHAE Study): A Matched Case Control Study at the Medical and Paediatric wards of Mbarara Regional Referral Hospital-South Western Uganda
(Research square, 2022-09-07)Background: This study aimed to determine the association between pre-hospital antibiotic exposure and level of bacterial resistance among adult and paediatric patients. Methods: In the study, 79 antibiotic pre-exposed ... -
Ligand-protein interactions of plant-isolated (9z,12z)-octadeca-9,12-dienoic acid with B-ketoacyl-Acp synthase (KasA) in potential anti-tubercular drug designing
(Scientific African, 2021)Mycobacterium tuberculosis remains one of the world’s contributors to mortality. With the emergence of SARS-CoV-2 coinfections, patients with TB are predisposed to being more heavily weighed down by COVID-19 disease and ... -
Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review
(Scientific African, 2021)Hepatitis C Virus (HCV) infection represents a huge burden on healthcare systems world- wide. Vachellia nilotica ( V. nilotica ) is a widely used plant specie in folk medicine for viral diseases and in some communities for ... -
New Putative Antimicrobial Candidates: In silico Design of Fish-Derived Antibacterial Peptide-Motifs
(Frontiers in Bioengineering and Biotechnology, 2020)Antimicrobial resistance remains a great threat to global health. In response to the World Health Organizations’ global call for action, nature has been explored for novel and safe antimicrobial candidates. To date, fish ... -
Human Health Risk Assessment of Heavy Metals in Kampala (Uganda) Drinking Water
(Journal of Food Research, 2022)Levels of aluminium, arsenic, cadmium, chromium, copper, iron, mercury, manganese, nickel, lead and zinc in tap water, groundwater-fed protected spring and bottled water were determined. The cancer and non-cancer risks ... -
General Extraction, Isolation and Characterization Techniques in Drug Discovery: A Review
(International Journal of Sciences: Basic and Applied Research (IJSBAR), 2018)Extraction, isolation and characterization techniques of compounds from plant tissues are the basic foundations of drug discovery from plants. Research has been conducted using these techniques and publications are available ... -
Fundamental Methods in Drug Permeability, pKa, LogP and LogDx Determination
(Journal of Drug Research and Development, 2018)Potential drug molecular leads from plants are usually tested for their efficacy in bioactivity assays in preclinical trials. This is followed by testing for the properties of the molecular structures, if they can be ... -
Fish Mucus- a Neglected Reservoir For Antimicrobial Peptides
(Asian Journal of Pharmaceutical Research and Development, 2018)Antimicrobial resistance has posed a great global burden, with the fear that by 2050 it would have killed more people than cancer if nothing much is done about it. Alongside several attempts in place, zoo-therapy is becoming ... -
Drug-like properties of anticancer molecules elucidated from Eichhornia crassipes
(Journal of Pharmacognosy and Phytochemistry, 2018)Eichhornia crassipes is reported to have molecules that are active against liver, cervical, breast cancers and melanoma cells. This systematic review was conducted according to Cochrane hand book of systematic review and ... -
D-optimal mixture design optimized solid formulation containing fruits extracts of Momordica charantia and Abelmoschus esculentus
(PLoS ONE, 2022-06-24)Fruit extracts of Momordica charantia L. (Cucurbitaceae) and Abelmoschus esculentus (L.) Moench (Malvaceae) have shown promising antidiabetic activities in clinical trials. However, they remain underutilized due to ... -
Dietary Content and Potential Health Risks of Metals in Commercial Black Tea in Kampala (Uganda)
(Journal of Food Research, 2017)Tea (Camellia sinensis (L.) Kuntze) is among the most widely consumed non-alcoholic beverages. It is a rich source of essential dietary elements mainly potassium and manganese. Tea may also contain toxic metals such as ... -
Chromatographic, Mass and Cytotoxicity analysis of Isolates from Eichhornia crassipes’ Roots and Leaves against HepG2 and MCF7 cell lines
(Cogent Biology, 2021)Cancers remain one of the leading causes of death in the world. However, known conventional cancer medicines remain scarce, expensive and out of reach to many patients. To provide an alternative for the expensive therapies, ... -
Bacterial Cell Envelope Lysis and Hemotoxicity of Peptides Previously isolated From African Catfish, Clarias gariepinus
(East African Science, 2022-06)Background: The skin mucus layer of fish is endowed with biologics including, Antimicrobial peptides (AMPs) that offer a first line of defence against pathogens. Such peptides can either inhibit bacterial growth or completely ... -
Prevalence and Factors Associated With Adverse Drug Events Among Patients On Dolutegravir-Based Regimen At The Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: A Retrospective Cross-Sectional Study.
(Research square, 2022)Background: Highly Active Antiretroviral Therapy is efficacious in suppression of Human Immunodeficiency Virus (HIV) however; it is associated with numerous toxicities hence great effort has been put into development of ... -
Predictors of hospital‑acquired adverse drug reactions: a cohort of Ugandan older adults
(BMC Geriatrics, 2022)Background: Globally, it is estimated that the number of older adults will become 2 billion by 2050. The identification of the predictors of adverse drug reaction (ADR) in hospitalized older patients is crucial to the ... -
Off‑label antibiotic use among paediatric in‑patients: a mixed‑method prospective study at a tertiary hospital in southwestern Uganda
(International Journal of Clinical Pharmacy, 2020)Background: The off-label use of drugs to treat children is a global practice attributed to the traditional exclusion of children from clinical trials mainly due to practical and ethical reasons. Off-label drug use carries ... -
Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats
(Pharmacology, Biochemistry and Behavior, 2008)We previously reported significant sex differences in ethanol withdrawal (EW) recovery as well as in sensitivity to GABAA receptor modulators during EW. The aim of the present study was to determine if hormonal status ...