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dc.contributor.authorBaguma, Andrew
dc.contributor.authorMusinguzi, Benson
dc.contributor.authorMpeirwe, Moses
dc.contributor.authorBazira, Joel
dc.date.accessioned2022-01-21T08:43:48Z
dc.date.available2022-01-21T08:43:48Z
dc.date.issued2019-12-12
dc.identifier.citationBaguma, A., Musinguzi, B., Mpeirwe, M., & Bazira, J. (2019). Clindamycin Resistance among Methicillin Resistant Staphylococcus aureus Isolated from Human and Respective Household Swine in Greater Kabale Region—South Western Uganda. Advances in Infectious Diseases, 9(4), 285-294.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/1259
dc.description.abstractIntroduction: S. aureus is recognized as the common cause of nosocomial and community-acquired infections. Macrolide-Lincosamide-Streptogramin B (MLSB) is thought to be alternative therapies against MRSA infections. Clindamycin is the most favored agent because of exceptional pharmacokinetic characteristics. However, increasing resistance to clindamycin among MRSA strains is a serious challenge. The current study investigated the profile of clindamycin resistance among MRSA isolates from Humans, and their respective livestock (in particular swine) using D-test in greater Kabale region. Materials and Methods: Three hundred phenotypic MRSA isolates previously isolated from Humans and swine were confirmed by mecA PCR. We performed D-test using erythromycin (15 μg) and clindamycin (2 μg) discs in accordance to Clinical and Laboratory Standards Institute (CLSI) protocol. Results: Of all 300 MRSA isolates, 6% (n = 18) were sensitive to Erythromycin and Clindamycin (S). The rate of inducible clindamycin resistance (iMLSB) was 42% (n = 125) and 38% (n = 115) was resistance to both Erythromycin and clindamycin (cMLSB). However, 14% (n = 42) were resistant to erythromycin but sensitive to clindamycin (MS) without “D” zone negative. Conclusion: Clindamycin resistance (both cMLSB and iMLSB) among MRSA was high and “D” test should be adopted routinely during antimicrobial susceptibility testing by disc diffusion testing to rapidly detect iMLSB and cMLSB.en_US
dc.language.isoen_USen_US
dc.publisherAdvances in Infectious Diseasesen_US
dc.subjectClindamycin Resistanceen_US
dc.subjectCMLSB and iMLSB Phenotypesen_US
dc.subjectMRSAen_US
dc.titleClindamycin Resistance among Methicillin Resistant Staphylococcus aureus Isolated from Human and Respective Household Swine in Greater Kabale Region—South Western Ugandaen_US
dc.typeArticleen_US


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