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Characterization of Extended Spectrum Beta-lactamase Uropathogens Isolated from Refugees with Urinary Tract Infections in Nakivale Refugee Settlement Camp, Southwestern Uganda
(International STD Research & Reviews, 2024)The World Health Organization estimates one in four individuals has had at least one urinary tract infection (UTI) episode requiring treatment with an antimicrobial agent. At Nakivale refugee camp, the overwhelming number ... -
An Investigation Into Carbapenem Resistance in Enterobacteriaceae Among Outpatients With Urinary Tract Infection in Southwestern Uganda
(Cureus, 2024)Background and aim: Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, primarily caused by Enterobacteriaceae. The rise of carbapenem-resistant Enterobacteriaceae (CRE), complicates ... -
The Universal Vital Assessment (UVA) score at 6hourspost-resuscitation predicts mortality in hospitalized adults with severe sepsis in Mbarara, Uganda
(PLOS Global Public Health, 2024)Sepsis is the leading cause of global death with the highest burden found in sub-Saharan Africa (sSA). The Universal Vital Assessment (UVA) score is a validated resource-appropriate clinical tool to identify hospitalized ... -
Exploring Utilization of Early Infant Human Immunodeficiency Virus-Diagnostic Services at a District Hospital in Rural South Western Uganda. (; Patients’ and Health Workers’ Experiences)
(Asian Journal of Research in Medicine and Medical Science, 2024)Introduction: Early Infant Diagnosis (EID) among HIV Exposed Infants (HEIs) is tailored to improve the management of these infants. The use of Deoxyribonucleic Acid Polymerase Chain Reaction (DNA PCR) has been utilized in ... -
Assessing the knowledge, training and capacity of health workers in the diagnosis and management of soil-transmitted helminths and schistosomiasis in eastern Uganda
(Transactions of The Royal Society of Tropical Medicine and Hygiene, 2024)Background: Neglected tropical diseases (NTDs) affect millions of people in Africa, with Uganda bearing a significant burden. The World Health Organization (WHO) set a goal to reduce NTDs and improve access to diagnosis and ... -
Combination Activity of Standard Antituberculosis Drugs and Extracts of Medicinal Plants Commonly Used in Traditional Treatment of Tuberculosis in Uganda
(Advances in Infectious Diseases, 2024)Introduction: Resistance to antituberculosis drugs and adverse drug reactions remain the leading causes of tuberculosis therapeutic failure globally. Despite the increasing acceptance of medicinal plant use in combination ... -
Carbapenem‑resistant Enterobacteriaceae in the livestock, humans and environmental samples around the globe: a systematic review and meta‑analysis
(Scientific Reports, 2024)Carbapenem‑resistant Enterobacteriaceae (CRE) have diminished treatment options causing serious morbidities and mortalities. This systematic review and meta‑analysis assessed the prevalence and associated factors of ... -
Evaluation of OMNIgene Sputum and Ethanol Reagent for Preservation of Sputum Prior to Xpert and Culture Testing in Uganda
(Journal of Clinical Microbiology, 2019)Xpert MTB/RIF (Xpert) and culture are the most reliable methods for tuberculosis diagnosis but are still poorly accessible in many low-resource countries. We aimed to assess the effects of OMNIgene Sputum (OM-S) and ethanol ... -
Distribution and antifungal susceptibility profile of oropharyngeal Candida species isolated from people living with HIV in the era of universal test and treat policy in Uganda
(Therapeutic Advances in Infectious Disease, 2024)Background: Despite the increased frequency of oropharyngeal candidiasis among people living with human immunodeficiency virus (HIV), its management is no longer effective due to empirical treatment and emergence of ... -
Characterization of Antibiotic Resistance in Select Tertiary Hospitals in Uganda: An Evaluation of 2020 to 2023 Routine Surveillance Data
(Tropical Medicine and Infectious Disease, 2024)Antimicrobial resistance (AMR) is a public health concern in Uganda. We sought to conduct an extended profiling of AMR burden at selected Ugandan tertiary hospitals. We analyzed routine surveillance data collected between ... -
Assessing the quality of drinking water from selected water sources in Mbarara city, Southwestern Uganda
(PLoS ONE, 2024)This study assessed the physical, chemical, and microbiological quality with emphasis on risk score, source apportionment, geochemistry, feacal coliforms and water quality index of drinking water from selected water sources. ... -
Task Shifting and Skin Punch for the Histologic Diagnosis of Kaposi’s Sarcoma in Sub-Saharan Africa: A Public Health Solution to a Public Health Problem
(Oncology, 2015)Fueled by HIV, sub-Saharan Africa has the highest incidence of Kaposi’s sarcoma (KS) in the world. Despite this, KS diagnosis in the region is based mostly on clinical grounds. Where biopsy is available, it has traditionally ... -
Unravelling patient pathways in the context of antibacterial resistance in East Africa
(BMC Infectious Diseases, 2023)Background: A key factor driving the development and maintenance of antibacterial resistance (ABR) is individuals’ use of antibiotics (ABs) to treat illness. To better understand motivations and context for antibiotic use ... -
Prevalence of anti-leptospiral IgM and detection of pathogenic Leptospira species DNA in neonates presenting with clinical sepsis in Southwestern Uganda
(European Journal of Medical Research, 2022)Background: Leptospirosis is an emerging neglected zoonotic disease that presents with nonspecific signs/symptoms and it can be mistaken for other diseases. Owing to limited diagnostic capacity and unawareness, the data ... -
Mycobacterium tuberculosis mixed infections and drug resistance in sub-Saharan Africa: a systematic review
(African Health Sciences,, 2022)Background: Sub-Saharan Africa, is a region that records high rates of TB infection. Mycobacterium tuberculosis mixed strain infection, especially when the strains involved are of different susceptibilities, is an area of ... -
Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa: a call for action
(JAC-Antimicrobial Resistance, 2024)Background: In low- and middle-income countries, antibiotics are often prescribed for patients with symptoms of urinary tract infections (UTIs) without microbiological confirmation. Inappropriate antibiotic use can contribute ... -
Treatment seeking behaviours, antibiotic use and relationships to multi-drug resistance: A study of urinary tract infection patients in Kenya, Tanzania and Uganda
(PLOS Global Public Health, 2024)Antibacterial resistance (ABR) is a major public health threat. An important accelerating factor is treatment-seeking behaviour, including inappropriate antibiotic (AB) use. In many low and middle-income countries (LMICs) ... -
HIV-associated gut microbial alterations are dependent on host and geographic context
(Nature Communications, 2024)HIV-associated changes in intestinal microbiota are believed to be important drivers of disease progression. However, the majority of studies have focused on populations in high-income countries rather than in developing ... -
Bacteriological profile, antibiotic susceptibility and factors associated with neonatal Septicaemia at Kilembe mines hospital, Kasese District Western Uganda
(BMC microbiology, 2021)Introduction: Neonatal septicaemia is one of the most common leading causes of neonatal morbidity and mortality in developing countries. It is estimated to affect more than 30 million people worldwide annually, potentially ... -
Treatment seeking and antibiotic use for urinary tract infection symptoms in the time of COVID-19 in Tanzania and Uganda
(Journal of Global Health, 2024)Background: There is still little empirical evidence on how the outbreak of coronavirus disease 2019 (COVID-19) and associated regulations may have disrupted care-seeking for non-COVID-19 conditions or affected antibiotic ...
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