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dc.contributor.authorMpeirwe, Moses
dc.contributor.authorTaremwa, Ivan Mugisha
dc.contributor.authorOrikiriza, Patrick
dc.contributor.authorOgwang, Patrick Engeu
dc.contributor.authorSesaazi, Crispin Duncan
dc.contributor.authorBazira, Joel
dc.date.accessioned2023-02-13T08:10:22Z
dc.date.available2023-02-13T08:10:22Z
dc.date.issued2023
dc.identifier.citationMpeirwe, M., Taremwa, I.M., Orikiriza, P., Ogwang, P.E., Ssesazi, D. and Bazira, J. (2023) Anti-Mycobacterial Activity of Medicinal Plant Extracts Used in the Treatment of Tuberculosis by Traditional Medicine Practitioners in Uganda. Pharmacology & Pharmacy , 14, 33- 42.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/2765
dc.description.abstractTuberculosis (TB) remains a public health challenge and one of the leading causes of death worldwide. TB is preventable and curable. However, treatment of tuberculosis has continued to be difficult as a result of rapid increase of multidrug and extensively drug resistant strains of Mycobacterium tuberculosis. Medicinal plants have for centuries been traditionally used in treatment of tuberculosis and similar ailments. They possess antimicrobial properties which render them a new hope as a source of novel bioactive leads in the development of antimycobacterial agents. In this study, 2 plant species commonly used traditionally in Uganda for treatment of tuberculosis, Zanthoxylum leprieurii and Rubia cordifolia were screened for in vitro antimycobacterial activity against Mycobacterium tuberculosis strains; pan sensitive MTB H37Rv, Rifampicin resistant TMC 331 strain and two wild strains (one rifampicin resistant and another one rifampicin susceptible). Antimycobacterial activity of aqueous, ethanolic and methanolic plant extracts was determined using Resazurin Microtiter Assay (REMA). Both plant extracts exhibited significant in vitro antimycobacterial activity against all strains of Mycobacterium tuberculosis. Minimum inhibitory concentrations (MIC) of methanolic crude extracts of both plants ranged from 23.4 μg/mL to 187.5 μg/mL. Comparatively, methanol extracts of both plants possessed superior antimycobacterial activity against all Mycobacterium tuberculosis strains. Our findings indicated that both plants exhibited activity against susceptible and re- sistant strains of Mycobacterium tuberculosis. While antimycobacterial activity of Z. leprieurii confirms results from previous studies, activity of the extracts of R. cordifolia is reported for the first time in East Africa. Further studies aimed at determining the effects of combination of these plant extracts and standard anti-TB drugs should be carried out.en_US
dc.description.sponsorshipWorld Bank and Government of Ugandaen_US
dc.language.isoen_USen_US
dc.publisherPharmacology & Pharmacyen_US
dc.subjectTuberculosisen_US
dc.subjectAntimycobacterial Activityen_US
dc.subjectMedicinal Plantsen_US
dc.subjectZanthoxylum leprieuriien_US
dc.subjectRubia cordifoliaen_US
dc.titleAnti-Mycobacterial Activity of Medicinal Plant Extracts Used in the Treatment of Tuberculosis by Traditional Medicine Practitioners in Ugandaen_US
dc.typeArticleen_US


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